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Research
The Swiss organ allocation system for donor lungs was implemented on 1 July 2007. The effects of this implementation on patient selection, intensive care unit course, outcomes and intensive care costs are unkn...
Transplantation Research 2014 3:9
Published on: 1 April 2014
Review
In countries where presumed consent for organ donation does not apply, health professionals (HP) are key players for identifying donors and obtaining their consent. This systematic review was designed to verif...
Transplantation Research 2014 3:8
Published on: 14 March 2014
Research
Tacrolimus is a widely used calcineurin inhibitor in kidney transplantation. It is available as twice-daily Prograf® (Tac-BID) and once-daily Advagraf® (Tac-OD). Although therapeutically equivalent, some patie...
Transplantation Research 2014 3:7
Published on: 10 March 2014
Research
The volume and outcome relationship for transplant procedures has become one of the major topics during discussions about consequences following the organ transplantation scandal of wait-list manipulations in ...
Transplantation Research 2014 3:5
Published on: 10 February 2014
Editorial
Transplantation Research 2014 3:6
Published on: 10 February 2014
Reviewer Acknowledgement
The Editors of Transplantation Research would like to thank all our reviewers who have contributed to the journal in Volume 2 (2013).
Transplantation Research 2014 3:3
Published on: 5 February 2014
Research
We analyzed all PRA-negative patients who received a first kidney transplant from an HLA-identical living donor. The patients received no antibody induction. An intraoperative bolus of 500 mg of methylpredniso...
Transplantation Research 2014 3:4
Published on: 3 February 2014
Research
Determining eligibility for a kidney transplant is one of the most important decisions facing nephrologists. It is assumed that the harm of kidney transplantation is minimal and most will benefit. The purpose ...
Transplantation Research 2014 3:2
Published on: 8 January 2014
Research
Literature on the timing of rabbit antithymocyte globulin (rATG) induction and its effects on kidney transplant outcomes is limited. The manufacturer recommends that the first dose be given intra-operatively, ...
Transplantation Research 2014 3:1
Published on: 3 January 2014
Review
Donation after circulatory death (DCD) is a promising solution to the critical shortage of donor graft tissue. Maintaining organ viability after donation until transplantation is essential for optimal graft fu...
Transplantation Research 2013 2:19
Published on: 27 November 2013
Review
Alemtuzumab (Campath) is a monoclonal antibody that has a profound lymphocyte-depleting effect, targeting the CD52 antigen that is present on all lymphocytes. Alemtuzumab has been used for the treatment of chr...
Transplantation Research 2013 2(Suppl 1):S5
Published on: 20 November 2013
This article is part of a Supplement: Volume 2 Supplement 1
Review
Mammalian target of rapamycin (mTOR) inhibitors are currently considered an alternative immunosuppressive treatment that can prevent the nephrotoxicity, viral infections and malignancies that are associated wi...
Transplantation Research 2013 2(Suppl 1):S3
Published on: 20 November 2013
This article is part of a Supplement: Volume 2 Supplement 1
Review
Transplantation is more predictable than it was 20 to 30 years ago and innovation over the last 20 years has been rapid, delivering substantial short-term and medium-term improvements. The challenges ahead are...
Transplantation Research 2013 2(Suppl 1):S1
Published on: 20 November 2013
This article is part of a Supplement: Volume 2 Supplement 1
Review
JAK3 inhibition with the CP-690,550 compound has an immunosuppressive potency in murine models, nonhuman primates and humans. This drug blocks STAT5 activation in most T-cell subpopulations but less effectivel...
Transplantation Research 2013 2(Suppl 1):S6
Published on: 20 November 2013
This article is part of a Supplement: Volume 2 Supplement 1
Review
Renal transplantation is the treatment of choice for end-stage renal failure. Although advances in immunosuppression have led to improvements in short-term outcomes, graft survival beyond 5 to 10 years has not...
Transplantation Research 2013 2(Suppl 1):S4
Published on: 20 November 2013
This article is part of a Supplement: Volume 2 Supplement 1
Review
The known role of mammalian target of rapamycin (mTOR) in the immune response has been rapidly evolving, from what was once thought to be a simple immunosuppressive antiproliferative effect on T cells to a ver...
Transplantation Research 2013 2(Suppl 1):S2
Published on: 20 November 2013
This article is part of a Supplement: Volume 2 Supplement 1
Research
Renal transplant candidates are at high risk of coronary artery disease (CAD). We sought to develop a new risk score model to determine the pre-test probability of the occurrence of significant CAD in renal tr...
Transplantation Research 2013 2:18
Published on: 1 November 2013
Research
Immune monitoring by flow cytometry is a fast and highly informative way of studying the effects of novel therapeutics aimed at reducing transplant rejection or treating autoimmune diseases. The ONE Study cons...
Transplantation Research 2013 2:17
Published on: 25 October 2013
Research
Allograft fibrosis still remains a critical problem in transplantation, including heart transplantation. The IL-13/TGF-β1 interaction has previously been identified as a key pathway orchestrating fibrosis in diff...
Transplantation Research 2013 2:16
Published on: 22 October 2013
Research
Kidney transplant recipients are recognized as a vulnerable population that is at increased risk of adverse health outcomes. However, there have been few studies that have compared hospital-related morbidity o...
Transplantation Research 2013 2:15
Published on: 24 August 2013
Research
No study to date has evaluated the efficacy and safety of everolimus with reduced-exposure cyclosporine in Japanese de-novo renal transplant (RTx) patients.
Transplantation Research 2013 2:14
Published on: 16 July 2013
Research
The first crucial step in transplantation appears to be the effective rinsing of the graft during organ procurement. Even though there is strong suspicion that ex situ perfusion results in better rinsing of the g...
Transplantation Research 2013 2:13
Published on: 9 July 2013
Clinical trial protocol
Simultaneous pancreas kidney transplantation (SPK), pancreas transplantation alone (PTA) or pancreas transplantation after kidney (PAK) are the only curative treatment options for patients with type 1 (juvenil...
Transplantation Research 2013 2:12
Published on: 1 July 2013
Research
The most important limiting factor in kidney transplantation is the scarcity of donor organs. Consequently, there is an increased use worldwide of kidneys from older deceased donors. High donor age is a known ...
Transplantation Research 2013 2:11
Published on: 26 June 2013
Review
Stem cells have been studied for many years for their potential to repair damaged organs in the human body. Although many different mechanisms have been suggested as to how stem cells may initiate and facilita...
Transplantation Research 2013 2:10
Published on: 20 June 2013
