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  1. Research

    13C glucose labelling studies using 2D NMR are a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys

    The aim of this study is to determine the feasibility of using nuclear magnetic resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissu...

    Jay Nath, Tom Smith, Alex Hollis, Sam Ebbs, Sefa W. Canbilen, Daniel A. Tennant, Andrew R. Ready and Christian Ludwig

    Transplantation Research 2016 5:7

    Published on: 5 August 2016

  2. Clinical trial protocol

    Protocol for a prospective randomized controlled trial of recipient remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial)

    Ischaemic reperfusion (IR) injury is a major cause of graft loss, morbidity and mortality following orthotopic liver transplantation (OLT). Demand for liver transplantation has resulted in increasing use of ma...

    Francis P. Robertson, Rup Goswami, Graham P. Wright, Barry Fuller and Brian R. Davidson

    Transplantation Research 2016 5:4

    Published on: 6 April 2016

  3. Clinical trial protocol

    The role of CYP3A5 polymorphism and dose adjustments following conversion of twice-daily to once-daily tacrolimus in renal transplant recipients

    Tacrolimus is available as twice-daily Prograf® (Tac-BID) and the once-daily formulation, Advagraf® (Tac-OD). Although therapeutically equivalent, some transplant recipients require dose adjustments to achieve...

    Alina S. R Zaltzman, Lauren A. Glick, Jeffrey S. Zaltzman, Michelle Nash, Michael Huang and G. V. Ramesh Prasad

    Transplantation Research 2016 5:2

    Published on: 28 January 2016

  4. Research

    Immunomodulating effects of the anti-viral agent Silibinin in liver transplant patients with HCV recurrence

    Silibinin has been shown to have anti-HCV activity and immune-modulating properties by regulating dendritic cell (DC) function. DCs are antigen-presenting cells that, together with regulatory T cells (Treg), p...

    Antonino Castellaneta, Antonio Massaro, Maria Rendina, Francesca D’Errico, Sonia Carparelli, Salvatore Fabio Rizzi, Angus W. Thomson and Alfredo Di Leo

    Transplantation Research 2016 5:1

    Published on: 20 January 2016

  5. Review

    Reviewing 15 years of experience with sirolimus

    Here, we review 15 years of clinical use of sirolimus in our transplant center, in context with the developing immunosuppressive strategies use worldwide. The majority of studies were conducted in de novo kidn...

    Helio Tedesco Silva Jr, Claudia Rosso Felipe and Jose Osmar Medina Pestana

    Transplantation Research 2015 4(Suppl 1):28

    Published on: 22 December 2015

    This article is part of a Supplement: Volume 4 Supplement 1

  6. Review

    Practical considerations for the use of mTOR inhibitors

    Immunosuppressive therapy after kidney transplantation is based on calcineurin inhibitors (CNI). In most cases CNI therapy is combined with mycophenolate and steroids. In spite of good short-term results this ...

    Fritz Diekmann and Josep M. Campistol

    Transplantation Research 2015 4(Suppl 1):29

    Published on: 22 December 2015

    This article is part of a Supplement: Volume 4 Supplement 1

  7. Research

    Contraindications to kidney transplantation: uneven grounds?

    Determining eligibility for a kidney transplant is an important decision. Practice guidelines define contraindications to transplantation; however many are not evidence based. Canadian guidelines recommend tha...

    Bryce A. Kiberd, Meteb M AlBugami, Romuald Panek and Karthik Tennankore

    Transplantation Research 2015 4:2

    Published on: 21 July 2015

  8. Research

    Vitamin D and cinacalcet administration pre-transplantation predict hypercalcaemic hyperparathyroidism post-transplantation: a case-control study of 355 deceased-donor renal transplant recipients over 3 years

    The effects of pre-transplantation medication for secondary hyperparathyroidism on post-transplantation parathyroid hormone (PTH) and calcium levels have not yet been conclusively determined. Therefore, this s...

    Frank-Peter Tillmann, Carolin Wächtler, Anita Hansen, Lars Christian Rump and Ivo Quack

    Transplantation Research 2014 3:21

    Published on: 31 December 2014

  9. Research

    Effect of left atrial and ventricular abnormalities on renal transplant recipient outcome—a single-center study

    Premature cardiovascular (CV) death is the commonest cause of death in renal transplant recipients. Abnormalities of left ventricular (LV) structure (collectively termed uremic cardiomyopathy) and left atrial ...

    Rajan K Patel, Christopher Pennington, Kathryn K Stevens, Alison Taylor, Keith Gillis, Elaine Rutherford, Nicola Johnston, Alan G Jardine and Patrick B Mark

    Transplantation Research 2014 3:20

    Published on: 3 December 2014

  10. Research

    Multipotent adult progenitor cells decrease cold ischemic injury in ex vivo perfused human lungs: an initial pilot and feasibility study

    Primary graft dysfunction (PGD) is a significant cause of early morbidity and mortality following lung transplantation. Improved organ preservation techniques will decrease ischemia-reperfusion injury (IRI) co...

    Saverio La Francesca, Anthony E Ting, Jason Sakamoto, Jessica Rhudy, Nicholas R Bonenfant, Zachary D Borg, Fernanda F Cruz, Meagan Goodwin, Nicholas A Lehman, Jennifer M Taggart, Robert Deans and Daniel J Weiss

    Transplantation Research 2014 3:19

    Published on: 1 November 2014

  11. Research

    Factors influencing survival after kidney transplant failure

    The failure of a kidney transplant is now a common reason for initiation of dialysis therapy. Kidney transplant recipients commencing dialysis have greater morbidity and mortality than transplant-naïve, incide...

    Jennifer A McCaughan, Christopher C Patterson, Alexander P Maxwell and Aisling E Courtney

    Transplantation Research 2014 3:18

    Published on: 24 September 2014

  12. Research

    Cascade plasmapheresis (CP) as a preconditioning regime in ABO-incompatible live related donor liver transplants (ABOi-LDLT)

    ABO-incompatible live donor liver transplant (ABOi-LDLT) is being widely done to bridge the gap of demand and supply of organs. Different desensitization regimes are being used to reduce titer of blood group a...

    Aseem Kumar Tiwari, Prashant Pandey, Geet Aggarwal, Ravi C Dara, Ganesh Rawat, Vimarsh Raina and Arvinder Singh Soin

    Transplantation Research 2014 3:17

    Published on: 12 September 2014

  13. Research

    The feasibility and applications of non-invasive cardiac output monitoring, thromboelastography and transit-time flow measurement in living-related renal transplantation surgery: results of a prospective pilot observational study

    Delayed graft function (DGF) remains a significant and detrimental postoperative phenomenon following living-related renal allograft transplantation, with a published incidence of up to 15%. Early therapeutic ...

    Stephen J Goodyear, James Barnes, Caitlin E Imray, Robert Higgins, For T Lam, S Habib Kashi, Lam C Tan and Christopher HE Imray

    Transplantation Research 2014 3:16

    Published on: 29 August 2014

  14. Commentary

    Active video gaming in patients with renal transplant: a pilot study

    Patients with renal transplant are at higher risk of mortality from cardiovascular disease (CVD) compared with the general population. Physical activity has been shown to reduce the risk of CVD mortality in th...

    Dorothy Wei Yun Wang, Laura L Sills, Sara B MacDonald, Ziv Maianski and Ian Alwayn

    Transplantation Research 2014 3:15

    Published on: 9 August 2014

  15. Research

    Development of a preclinical model of donation after circulatory determination of death for translational application

    Extracorporeal membranous oxygenation is proposed for abdominal organ procurement from donation after circulatory determination of death (DCD). In France, the national Agency of Biomedicine supervises the proc...

    Géraldine Allain, Thomas Kerforne, Rodolphe Thuret, Pierre-Olivier Delpech, Thibaut Saint-Yves, Michel Pinsard, Thierry Hauet, Sébastien Giraud, Christophe Jayle and Benoît Barrou

    Transplantation Research 2014 3:13

    Published on: 14 June 2014

  16. Clinical trial protocol

    An in-progress, open-label, multi-centre study (SAILOR) evaluating whether a steroid-free immunosuppressive protocol, based on ATG induction and a low tacrolimus dose, reduces the incidence of new onset diabetes after transplantation

    Corticosteroids and calcineurin inhibitors (CNIs) are included in renal transplantation immunosuppressive protocols around the world. Well-known side effects are associated with the use of these drugs, includi...

    Jana Ekberg, Henrik Ekberg, Bente Jespersen, Ragnar Källen, Karin Skov, Michael Olausson, Lars Mjörnstedt and Per Lindnér

    Transplantation Research 2014 3:12

    Published on: 13 June 2014

  17. Research

    Safety and efficacy of outpatient bronchoscopy in lung transplant recipients - a single centre analysis of 3,197 procedures

    Bronchoscopy represents an important diagnostic and therapeutic tool in the management of lung transplant (LTx) recipients. Outpatient bronchoscopy reduces health costs and may improve quality of life amongst ...

    Jessica Rademacher, Hendrik Suhling, Mark Greer, Axel Haverich, Tobias Welte, Gregor Warnecke and Jens Gottlieb

    Transplantation Research 2014 3:11

    Published on: 27 May 2014

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