|
Baseline characteristics
|
Total (n = 477)
|
Pre (n = 124)
|
Post (n = 353)
|
P value
|
|---|
|
Recipient characteristics
|
|---|
|
Mean recipient age (years)
|
477
|
48.5 ± 13.3a
|
51.3 ± 13.1
|
0.04
|
|
Recipient sex
|
0.14
|
|
Male
|
296
|
70 (56.5%)
|
226 (64.0%)
|
|
Female
|
181
|
54 (43.6%)
|
127 (36.0%)
|
|
Race
| | | |
0.19
|
|
Caucasian
|
289
|
69 (55.7%)
|
220 (62.3%)
|
|
Non-Caucasian
|
188
|
55 (44.4%)
|
133 (37.7%)
|
|
Mean height (cm)
|
477
|
167.9 ± 11.9
|
168.1 ± 9.9
|
0.83
|
|
Mean weight (kg)
|
477
|
77.7 ± 18.1
|
75.1 ± 16.3
|
0.13
|
|
Body mass index (kg/m2)
|
477
|
27.6 ± 5.8
|
26.5 ± 5.2
|
0.07
|
|
Cause of ESRD
|
0.58
|
|
Diabetes
|
83
|
17 (13.7%)
|
66 (18.7%)
|
|
Glomerulonephritis
|
171
|
51 (41.1%)
|
120 (34.0%)
|
|
Polycystic kidney disease
|
55
|
15 (12.1%)
|
40 (11.3%)
|
|
Hypertension
|
48
|
12 (9.7%)
|
36 (10.2%)
|
|
Other
|
120
|
29 (23.4%)
|
91 (25.8%)
|
|
Transplant number
|
0.57
|
|
First graft
|
396
|
105 (84.7%)
|
291 (82.4%)
|
|
Re-graft
|
81
|
19 (15.3%)
|
62 (17.6%)
|
|
Median PRA (%)b
|
477
|
15 (0,49)
|
10 (0,46)
|
0.23
|
|
Median length of stay (days)b
|
477
|
9 (7,12)
|
11 (8,16)
|
0.01
|
|
Donor characteristics
|
|
Mean donor age (years)
|
477
|
45.8 ± 13.9
|
48.5 ± 14.2
|
0.05
|
|
Donor sex
|
1.00
|
|
Male
|
250
|
65 (52.4%)
|
185 (52.4%)
|
|
Female
|
227
|
59 (47.8%)
|
168 (47.6%)
|
|
Median donor CrCl (mL/min)b, c
|
445 (117/328)d
|
110.6 (92.9, 137.6)
|
110.5 (91.5, 140.9)
|
0.88
|
|
Mean CIT (min)e
|
244 (38/206)d
|
954.7 ± 314.7
|
810.7 ± 375.2
|
0.03
|
|
Donor type (%)
|
0.002
|
|
Deceased
|
312
|
67 (54.0%)
|
245 (69.4%)
|
|
Living
|
165
|
57 (46.0%)
|
108 (30.6%)
|
|
DCD kidneys
| |
|
No
|
443
|
124 (100%)
|
319 (90.4%)
|
<0.001
|
|
Yes
|
34
|
0 (0%)
|
34 (9.6%)
| |
|
Transplant characteristics
|
|
Transplant era (%)
| | | |
<0.001
|
|
2002 to 2004
|
86
|
31 (25.0%)
|
55 (15.6%)
|
|
2005 to 2007
|
186
|
61 (49.2%)
|
125 (35.4%)
|
|
2008 to 2009
|
205
|
32 (25.8%)
|
173 (49.0%)
|
|
Delayed graft function
| | | | |
|
No
|
332
|
99 (79.8%)
|
233 (66.0%)
|
0.004
|
|
Yes
|
145
|
25 (20.2%)
|
120 (34.0%)
| |
|
Maintenance CNI
|
<0.001
|
|
Tacrolimus
|
360
|
78 (62.9%)
|
282 (79.9%)
|
|
Cyclosporine
|
106
|
45 (36.3%)
|
61 (17.3%)
|
|
CNI-free
|
11
|
1 (0.8%)
|
10 (2.8%)
|
- CIT, cold ischemia time; CNI, calcineurin inhibitor; CrCl, creatinine clearance; DCD, donation after cardiac death; ESRD, end stage renal disease; PRA, panel reactive antibodies.
- aPlus-minus values are means ± standard deviation.
- bMedian (interquartile range).
- cCreatinine clearance estimated using the Cockcroft-Gault formula.
- dTotal number assessed (Pre group/Post group).
- eDeceased donor kidney transplants only.
