Induction with interleukin-2 antagonist for transplantation of kidneys from older deceased donors: an observational study

Table 4 Two year death-censored Cox regression analysis

	Univariable			Multivariable model 1			Multivariable model 2
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Delayed graft function	5.21	2.17 to 12.48	< 0.001	5.04	2.05 to 12.42	< 0.001	5.41	2.20 to 13.34	< 0.001
IL-2 minus	4.13	1.78 to 9.57	0.001	4.59	1.91 to 11.02	0.001	3.81	1.53 to 9.49	0.004
Time on dialysis (per year)	1.23	0.94 to 1.63	0.1	1.20	0.89 to 1.62	ns	1.22	0.91 to 1.63	ns
Recipient gender	1.72	0.65 to 4.58	0.3	1.26	0.46 to 3.43	ns	1.23	0.45 to 3.34	ns
Recipient age	1.01	0.98 to 1.05	0.5	1.00	0.97 to 1.03	ns	1.00	0.97 to 1.04	ns
Steroid-resistant rejection	3.65	1.52 to 8.74	0.004				2.52	1.01 to 6.29	0.05

N = 232; 25 graft loss, no missing variables.
The following variables were tested in the univariable model but not included in the multivariable model: CMV-positive donor, CMV-positive recipient, presence of HLA antibodies, donor age, donor gender, any HLA-A, HLA-B or HLA-DR mismatch, type of calcineurin inhibitor (tacrolimus versus CsA), cold ischemia time and presence of acute rejection episodes 90 or 180 days after transplantation.

ISSN: 2047-1440