Induction with interleukin-2 antagonist for transplantation of kidneys from older deceased donors: an observational study

Table 3 Two year uncensored graft loss Cox regression analysis

	Univariable			Multivariable model 1			Multivariable model 2
	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Delayed graft function	3.58	1.93 to 6.65	< 0.001	3.12	1.65 to 5.87	< 0.001	3.23	1.82 to 6.09	< 0.001
IL-2 minus	2.63	1.45 to 4.78	0.001	2.28	1.22 to 4.30	0.01	2.02	1.04 to 3.93	0.04
Time on dialysis (per year)	1.28	1.05 to 1.57	0.02	1.27	1.01 to 1.60	0.04	1.27	1.01 to 1.61	ns
Recipient age (per year)	1.03	1.00 to 1.06	0.03	1.02	0.99 to 1.05	ns	1.02	0.99 to 1.05	ns
Any HLA-A mismatch	0.61	0.32 to 1.16	0.1	0.74	0.38 to 1.44	ns	0.68	0.35 to 1.34	ns
Tacrolimus versus CsA	0.34	0.08 to 1.41	0.1	0.44	0.10 to 1.98	ns	0.46	0.10 to 2.11	ns
Recipient gender (male)	1.70	0.82 to 3.54	0.2	1.41	0.66 to 2.99	ns	1.36	0.64 to 2.90	ns
Donor gender (male)	0.72	0.40 to 1.30	0.3	0.80	0.43 to 1.49	ns	0.80	0.43 to 1.50	ns
Steroid-resistant rejection	2.17	1.01 to 4.67	0.05	-	-	-	1.80	0.78 to 4.15	ns

N = 232; 42 graft loss, no missing variables.
The following variables were tested in the univariable model but not included in the multivariable model: CMV-positive donor, CMV-positive recipient, presence of HLA antibodies, donor age, any HLA-B or HLA-DR mismatch, cold ischemia time and presence of acute rejection episode 90 or 180 days after transplantation.

ISSN: 2047-1440