|
MFI (mean ± SD)
|
pDC
| |
mDC
| |
|---|
| |
Pre
|
Post
|
p
|
Pre
|
Post
|
p
|
|---|
|
HLA-DR
|
1673.5 ± 525.4
|
1523.4 ± 531.1
|
0.0092
|
2867.8 ± 440.9
|
2661.0 ± 573.2
|
0.1507
|
|
CD83
|
548.5 ± 187.7
|
755.0 ± 683.6
|
0.3982
|
374.9 ± 108.1
|
620.7 ± 392.5
|
0.0865
|
|
CD86
|
714.7 ± 174.0
|
743.6 ± 139.0
|
0.6359
|
1462.2 ± 322.8
|
1303.2 ± 328.0
|
0.4298
|
|
ICOSL
|
554.1 ± 223.8
|
640.4 ± 209.8
|
0.5265
|
498.2 ± 257.8
|
501.2 ± 133.7
|
0.9219
|
|
PD-L1
|
316.1 ± 110.7
|
376.8 ± 111.7
|
0.1848
|
272.0 ± 68.9
|
326.1 ± 88.6
|
0.1311
|
|
HLA-G
|
356.7 ± 57.8
|
409.9 ± 62.3
|
0.0583
|
567.7 ± 120.5
|
587.5 ± 108.4
|
0.6944
|
|
IL-T4
|
2303.6 ± 632.8
|
2743.4 ± 718.6
|
0.0165
|
1797.7 ± 424.0
|
2294.4 ± 570.7
|
0.0669
|
|
CD39
|
349.7 ± 116.9
|
437.8 ± 143.6
|
0.0456
|
1516.8 ± 269.2
|
1761.7 ± 527.6
|
0.2601
|
|
PD-L1/CD86
|
0.447 ± 0.110
|
0.5217 ± 0.197
|
0.3830
|
0.189 ± 0.042
|
0.268 ± 0.116
|
0.0929
|
- PBMC were analyzed before and after iv-SIL treatment by flow cytometry, as described in the “Methods” section, and the overall analysis of HLA-DR, CD83, CD86, ICOSL, PD-L1, HLA-G, IL-T4, and CD39 expression (MFI, mean SD) as well as the PD-L1/CD86 ratio on mDC and pDC is reported. Italicized values denote significance
