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Table 2 Overview of studies with everolimus

From: Practical considerations for the use of mTOR inhibitors

Author Study arm Control arm Outcome
Budde et al. [10, 11] Bas + CsA + MPS + S early conversion to EVR Bas + CsA + MPS + S Better GFR EVR arm at 1 yr and at 5 yrs (72 vs. 62 mL/min at 1 yr); overall higher rate of AR
Mjörnstedt et al. [16] CsA + MPS + S early conversion to EVR (7 weeks) CsA + MPS + S GFR change 4.9 vs 0 mL/min (EVR vs CsA)
Langer et al. [17] Bas + Tac low + EVR + S + conversion Tac very low Bas + Tac low + EVR + S No difference in AR post-conversion; GFR 57 vs. 51 mL/min (p = 0.0299)
  1. S steroids, CsA Cyclosporine A, Tac Tacrolimus, AR acute rejection rate, WD withdrawal, GFR glomerular filtration rate, Bas Basiliximab, MPS Mycophenolate Sodium, EVR Everolimus