Vitamin D and cinacalcet administration pre-transplantation predict hypercalcaemic hyperparathyroidism post-transplantation: a case-control study of 355 deceased-donor renal transplant recipients over 3 years

Table 1 Overview statistical results of continuous and categorical variables of transplant group A (control) and transplant group B (cinacalcet) on follow-up

	Transplant group A control ( n = 300, 84.5%)			Transplant group B cinacalcet ( n = 55, 15.5%)
Variable	Mean + SE	95% CI	Range	Mean + SE	95% CI	Range	p value	RR	95% CI
Dialysis vintage (years)	6.33 ± 0.19	5.95–6.70	23.62	6.88 ± 0.32	6.24–7.53	11.06	0.0417	-	-
Age at time of RTx (years)	53.67 ± 0.73	52.2–55.1	54.9	55.1 ± 1.3	52.6–57.6	33.7	0.5915	-	-
Creatinine (mg/dL)	1.81 ± 0.04	1.73–1.90	4.80	1.64 ± 0.09	1.45–1.83	3.40	0.0589	-	-
Calcium (mmol/L)	2.33 ± 0.01	2.30–2.35	1.42	2.42 ± 0.03	2.37–2.48	0.97	0.0045	1.2	1.1–1.4
Phosphate (mmol/L)	1.06 ± 0.17	1.02–1.09	1.83	0.95 ± 0.04	0.87–1.03	2.02	0.0021	0.2	0.1–0.7
AP (U/L)	83 ± 3	78–89	545	100 ± 6	78–101	262	0.0608	-	-
PTH 4 weeks post-transplant (pmol/L)	20.3 ± 1.6	17.2–23.5	332	40.7 ± 4.0	32.8–48.7	135	0.0000	1.5	1.2–1.8
PTH on follow-up (pmol/L)	18.4 ± 2.3	13.8–23.0	474.9	26.2 ± 2.3	21.6–30.8	72.4	0.0000^a	-	-
eGFR (CKD-EPI formula)	44.4 ± 1.2	42.0–46.7	121.6	47.4 ± 2.6	42.1–52.6	86.3	0.2435	-	-
Follow-up after RTx (years)	3.26 ± 0.12	3.03–3.48	8.08	3.50 ± 0.26	2.98–4.03	7.57	0.3641	-	-
Gender (%)	♂ 60.3	♀ 39.7	-	♂ 50.9	♀ 49.1	-	0.2330	-	-
Parathyroidectomy^b (%)	Yes 27.3	No 72.7	-	Yes 16.4	No 83.6	-	0.0948	-	-
Cinacalcet use on waiting list (%)	Yes 14.3	No 85.7	-	Yes 45.5	No 54.5	-	0.0000	5.0	2.7–9.3
Vitamin D use on waiting list^b (%)	Yes 60.0	No 40.0	-	Yes 65.5	No 35.5	-	0.5481	-	-
HPT pill burden on waiting list^b	0.72 ± 0.03	0.65–0.79	2	1.40 ± 0.08	1.24–1.56	2	0.0000	5.2	3.1–8.7

The Mann-Whitney U test and Fisher's exact test were used to compare for inter-group differences of continuous and categorical variables (a p value < 0.0071 was considered significant). To test for predictors of cinacalcet use after renal transplantation, univariate logistic regression was applied and risk ratios (RRs) of significant variables were calculated. Risk ratios and their respective 95% CI were calculated for increments as follows: calcium for an increase of 0.1 mmol/L, phosphate for an increase of 1.0 mmol/L and PTH 4 weeks post-transplant for an increase of 20 pmol/L. On univariate logistic regression, p values of significant variables (not shown in the table) were: 0.0039 for calcium, 0.0124 for phosphate, 0.0001 for PTH at time of RTx, 0.0000 for pill burden and 0.0000 for cinacalcet use on waiting list, respectively.
SE standard error, RTx renal transplantation, HPT hyperparathyroidism.
^aThe variable “PTH on follow-up” was not significant on logistic regression (p value 0.2003).
^bThe variables “parathyroidectomy”, “vitamin D use on waiting list” and HPT “pill burden on waiting list” encompass total and subtotal operative procedures, plain and active vitamin D derivatives and pill counts of cinacalcet and vitamin D derivatives, respectively.

ISSN: 2047-1440