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Table 2 Conversion data at 12 months by ethnicity

From: A prospective cohort conversion study of twice-daily to once-daily extended-release tacrolimus: role of ethnicity

Conversion

N

Mean (SD) Tac-BID dose (mg/day)

Mean (SD) [Tac] bid (ng/ml)

Mean (SD) Tac-OD dose (mg/day)

Mean (SD) [Tac] OD (ng/ml)

Percentage of cohort requiring >30% increase in Tac-OD dose

Total

488

3.53 (2.01)

5.49 (2.36)

3.75 (2.03)

5.15 (2.48)

15.7

Caucasian

282

3.23 (1.94)

5.58 (2.34)

3.42 (2.14)

5.48 (2.93)

13.5

East Asian

91

3.59 (2.27)

5.46 (2.35)

4.07 (2.28)

4.64 (1.38)

27.5*

South Asian

75

3.67 (2.25)

5.00 (1.62)

3.86 (2.31)

4.54 (1.38)

8.0

African Canadian

18

6.18 (3.87)

5.13 (1.43)

6.23 (4.20)

5.92 (2.33)

11.1

Middle Eastern

12

3.04 (1.76)

6.39 (3.26)

2.96 (1.57)

4.70 (2.30)

8.3

Other

10

2.89 (2.33)

5.42 (2.37)

2.06 (2.14)

5.40 (2.31)

20.0

  1. *P = 0.03 compared to all other cohorts.
  2. BID, twice daily; OD, once daily; SD, standard deviation; Tac, tacrolimus.