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Table 2 Non-population-based retrospective cohort studies reporting prognosis of patients with de novo post-transplant melanoma

From: Systematic review of melanoma incidence and prognosis in solid organ transplant recipients

First author (publication year) Location Transplant data source Number of cases of melanoma Staging data (number of patients with data) Outcomes
Brewer[20]a United States Mayo Clinic databases, OPTN, IPITTR 638 AJCC pathologic stage (67 tumors) Worse 3-year, cause-specific survival for Breslow 1.51 to 3.0 mm and Clark level III or IV in transplant recipients versus controls.
     Breslow depth (123)  
Frankenthaler[21] United States BIDMC Cutaneous Oncology Program database 4 (renal transplant)
15 (autoimmune disease)
AJCC stage (19) Similar relapse rates but worse overall survival in immunosuppressed group versus controls.
      Similar stage distribution at diagnosis compared to general melanoma database.
Matin[26] Europe SCOPE, AJCC 89 Breslow depth (83) Worse overall survival for Breslow >2 mm in transplant patients versus controls (HR 11.5, 95% CI 3.6 to 36.8), but not found for Breslow ≤2 mm (HR 1.5, 95% CI 0.31 to 6.9).
Clark level (82)
Ulceration (79)
      14 patients with metastasis.
Le Mire[22] United Kingdom Oxford renal transplant unit 10 Breslow depth (10)
Clark level (10)
Ulceration (10)
1 patient died from metastatic melanoma (Breslow 4.5 mm).
      No recurrence in other cases (all <1 mm).
Veness[23] Australia St Vincent Hospital, Sydney 8 Regional lymph node status (2) 4 deaths from metastasis.
Lévêque[24] France 9 centers 17 Breslow depth (16)
Clark level (16)
Ulceration (16)
4 deaths from metastasis
  1. aOverlap with three prior studies[25, 27, 28].
  2. AJCC, American Joint Committee on Cancer; BIDMC, Beth Israel Deaconess Medical Center; CI, confidence interval; HR, hazard ratio; IPITTR, Israel Penn International Transplant Tumor Registry (previously Cincinnati transplant tumor registry); OPTN, Organ Procurement and Transplantation Network; SCOPE, Skin Care in Organ Transplant Patients, Europe.