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Table 4 Cox model for biopsy-proven acute rejection, graft loss and death (n = 477) over 5-year follow-up

From: Timing of rabbit antithymocyte globulin induction therapy in kidney transplantation: an observational cohort study

  Number of eventsa Pre (n = 124)b Post (n = 353)b Hazard Ratio (95% CI)c P value
BPAR 68 (19/49) 17.6% 15.5% 0.90 (0.50, 1.64) 0.73
Graft loss 29 (8/21) 8.6% 10.1% 1.04 (0.41, 2.61) 0.94
Death 26 (10/16) 9.8% 6.3% 0.54 (0.21, 1.39) 0.20
Composite 103 (29/74) 27.0% 25.7% 0.94 (0.58, 1.53) 0.81
  1. aTotal number of events (Pre group/Post group).
  2. bCumulative probability of the outcome at 5-years using the Kaplan-Meier product limit method.
  3. cPredictors in the Cox model include: timing of induction, indication (high risk recipient and donor, high immunologic risk recipient, high risk donor and low immunologic risk recipient), occurrence of DGF, weight-adjusted total rATG dose, recipient age, recipient sex, recipient race (Caucasian or non-Caucasian), cause of ESRD (diabetes or non-diabetes), time on dialysis, peak PRA, re-graft status, recipient BMI, donor age, donor sex, donor type (living or deceased), and transplant era (2002 to 2004, 2005 to 2007 and 2008 to 2009).
  4. BMI, body mass index; BPAR, biopsy-proven acute rejection; CI, confidence interval; DGF, delayed graft function; ESRD, end stage renal disease; PRA, panel reactive antibodies; rATG, rabbit antithymocyte globulin.
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