Figure 5
From: IL-13 signaling via IL-13Rα2 triggers TGF-β1-dependent allograft fibrosis
Immunohistochemical analysis of the 'fibrotic program’ active in allogeneically transplanted grafts. Representative immunohistochemical stainings show strong positivity for Fas ligand, MMP-1, MMP-13, and β2-microglobulin in allogeneically (FVB into DBA/1) and for Gremlin-1 in syngeneically (DBA/1 into DBA/1) transplanted hearts explanted at day 100, in comparison to naive non-transplanted FVB hearts and acutely rejected (BALB/c into C57BL/6) allografts (20× magnification). MMP, matrix metalloproteinase.