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Table 2 Clinical translation of myeloid suppressor cell therapy in solid organ transplantation

From: Alternative approaches to myeloid suppressor cell therapy in transplantation: comparing regulatory macrophages to tolerogenic DCs and MDSCs

 

Origin

Time

Pre-clinical

Clinical

Ref.

M reg

Donor

Pre-

Mouse, pig, dog

TAIC- I, TAIC-II, The ONE Study

[13, 6, 16, 5658]

Tol-DC

Recipient

Peri-/post-

Rat, NHP

The ONE Study

[6, 18, 20, 53, 54]

DC-10

Recipient/Donor DC10 + recipient Tr-1

Peri-/post-

Rat

-

[59]

Rapa-DC

Donor-pulsed recipient

Pre-Post

Mouse

-

[25]

MDSC

Recipient

Peri-/Post-

Mouse

-

[60]