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Table 1 Main characteristics of different myeloid suppressor APCs

From: Alternative approaches to myeloid suppressor cell therapy in transplantation: comparing regulatory macrophages to tolerogenic DCs and MDSCs

  Human phenotype Function Mechanism Trafficking Ref.
M reg CD14-/low, CD16-, CD80-/low, CD40-/low, HLA-DR+, TLR2-, CD83-, CD163-/low T cell elimination, suppression of T cell proliferation IDO Lung, blood, liver, spleen [3, 1416]
Tol-DC HLA-DR+, low costimulation, CD14+, CD11b+, resistant to maturation Allo-Ag capture and presentation, suppression of T cell proliferation HO-1, EBl3, iNOS Spleen [8, 1720]
DC-10 CD14+, CD16+, CD83+, CD1a-, ILT4+, HLA-G+, IL-12- Induction T cell anergy, Tr-1 cell induction IL-10, ILT-4-HLA-G interactions Blood and secondary lymphoid organs [21]
Rapa-DC HLA-DR+, low costimulation, resistant to maturation, IL-12+ T cell hyporesponsiveness and apoptosis, T reg induction Low costimulation LN, spleen [2226]
MDSC HLA-DR-/low, CD11b++, CD14+, CD33+, CD34+ Suppression of T cell proliferation, cytokine production, apoptosis in T cells iNOS, Arg-1, ROS, PGE2, HO-1, TGF-β, cys depletion Blood, graft, spleen, LN [2732]