CYP2C19 | CYP3A4*18 a | CYP3A5*3 b | MDR1-3435 c | |||||
---|---|---|---|---|---|---|---|---|
Genotype (n) | T/T | T/C | G/G | A/G | A/A | C/C | C/T | T/T |
HomEM: n = 102 (%) | 93 (91.2) | 9 (8.8) | 55 (53.9) | 35 (34.3) | 12 (11.8) | 39 (38.2) | 51 (50.0) | 12 (11.8) |
D: n = 56 (%) | 50 (53.8) | 6 (66.7) | 32 (58) | 17 (48.6) | 7 (58.3) | 23 (59) | 29 (56.9) | 4 (33.3) |
R: n = 46 (%) | 43 (46.2) | 3 (33.3) | 23 (42) | 18 (51.4) | 5 (41.7) | 16 (41) | 22 (43.1) | 8 (66.7) |
HetEM: n = 130 (%) | 127 (97.7)d | 3 (2.3)d# | 65 (50.0) | 54 (41.5) | 11 (8.5) | 52 (40) | 64 (49.2) | 14 (10.8) |
D: n = 58 (%) | 58 (45.7) | 0 (0) | 30 (46.2) | 26 (48) | 2 (18.2) | 22 (42.3) | 32 (50) | 4 (28.6) |
R: n = 72 (%) | 69 (54.3) | 3 (100) | 35 (53.8) | 28 (52) | 9 (81.8) | 30 (57.7) | 32 (50) | 10 (71.4) |
PM: n = 34 (%) | 30 (88.2)d | 4 (11.8)d | 14 (41.2) | 20 (58.8) | Â | 16 (47.1) | 16 (47.1) | 2 (5.9) |
D: n = 19 (%) | 16 (53.3) | 3 (75) | 9 (64.3) | 10 (50) | 0 | 11 (68.8) | 6 (37.5) | 2 (100) |
R: n = 15 (%) | 14 (46.7) | 1 (25) | 5 (35.7) | 10 (50) | Â | 5 (31.2) | 10 (62.5) | 0 (0) |