Figure 2

Trump grades 2 to 4 of mitochondrial injury. Well-preserved mitochondria, showing elongated, orthodox conformation (injury grade 2). Mitochondria showing injury with condensation of their inner compartments, increased density of the matrices and expansion of intracristal spaces (grade 3). Mitochondria showing maximal, reversible injury with markedly condensed matrices and markedly expanded intracristal spaces. The inner compartments are expanded and those with flocculent densities may have irreversible injury (injury grade 4)